Who are the Colts playing this week?

The Indianapolis Colts will look to continue their dominant start to the season when they host the Tennessee Titans in Week 8 at Lucas Oil Stadium. Led by quarterback Daniel Jones and running back Jonathan Taylor, the Colts enter as heavy 14.5-point favorites after Dimers’ predictive model gave them a 90% chance to win based on 10,000 game simulations. Taylor is projected to rush for 96 yards and has the highest anytime touchdown probability on the slate at 68.8%, while tight end Tyler Warren and wideout Michael Pittman Jr. headline the passing attack. For Tennessee, rookie quarterback Cam Ward will need to rely on veteran running back Tony Pollard and emerging receiver Elic Ayomanor to keep the Titans within striking distance.

Kickoff is set for 4:25 p.m. ET, and early projections point toward a controlled Colts victory, with Dimers predicting a 30-16 final score and leaning slightly toward Under 47.5 points (-105) as the best bet. Indianapolis has been efficient on both sides of the ball, while the Titans continue to search for stability on offense following a slow start to the season. Expect the Colts to lean on Taylor and their defense to dictate tempo, while Tennessee looks to find enough big plays to stay competitive in an uphill divisional matchup.

Titans vs. Colts betting preview

Utilize the interactive widget below to discover the latest spread, over/under, and moneyline odds and probabilities for the Titans-Colts game at Lucas Oil Stadium.

This prediction and best bet for Sunday’s NFL matchup between the Titans and Colts is from Dimers.com, a dependable source for sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

Key information on the Titans vs. Colts matchup, including where the game is and what time it kicks off.

Teams: Tennessee Titans vs. Indianapolis Colts

Date: Sunday, October 26, 2025

Kickoff: 4:25 p.m. ET

Location: Lucas Oil Stadium

NFL standings: Current NFL division standings

NFL injuries: Check the latest updates to the official NFL injury report

Odds

The latest and best odds for the NFL showdown between the Titans and Colts.

Spread: Titans +14.5 (-108), Colts -14.5 (-110)

Moneyline: Titans +850, Colts -1350

Total: Over/Under 47.5 (-115/-105)

The odds and lines featured in this article are the best available from selected sports betting sites at the time of publication and are subject to change.

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Expert prediction: Titans vs. Colts

Using advanced data analysis and machine learning, the experts at Dimers have executed 10,000 simulations of Sunday’s Titans vs. Colts game.

According to Dimers’ popular predictive analytics model, the Colts are more likely to defeat the Titans at Lucas Oil Stadium. This prediction is based on the model giving the Colts a 90% chance of winning the game.

Elsewhere on the betting board, Dimers predicts that the bookies have gotten it right and the Titans and Colts each have a 50% chance of covering the spread, while the 47.5-point over/under has a 52% chance of staying under.

As always, these predictions and probabilities are accurate at the time of publication but are subject to potential changes.

Titans vs. Colts best bet

Our top pick for the Titans vs. Colts Week 8 NFL game is to bet on Under 47.5 points (-105).

This betting advice is formulated through detailed simulations and valuable betting intelligence, designed to bring you the best possible plays.

Score prediction for Titans vs. Colts

Dimers’ predicted final score for the Tennessee vs. Indianapolis game on Sunday has the Colts winning 30-16.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL player props: Sunday

NFL player props are a popular way to wager on Sunday’s game without necessarily betting on its outcome.

This article features the most likely first and anytime touchdown scorers for the Titans and Colts, as well as projected player stats.

Tennessee Titans

First touchdown scorer predictions

Tony Pollard: 6.9% probability

Elic Ayomanor: 5.5% probability

Tyjae Spears: 5.1% probability

Anytime touchdown predictions

Tony Pollard: 29.0% probability

Elic Ayomanor: 23.9% probability

Tyjae Spears: 22.4% probability

Projected box score leaders

QB passing yards: Cam Ward, 210 yards

Receiving yards: Elic Ayomanor, 41 yards

Rushing yards: Tony Pollard, 45 yards

Indianapolis Colts

First touchdown scorer predictions

Jonathan Taylor: 19.7% probability

Tyler Warren: 8.1% probability

Michael Pittman: 6.5% probability

Anytime touchdown predictions

Jonathan Taylor: 68.8% probability

Tyler Warren: 38.0% probability

Michael Pittman: 31.9% probability

Projected box score leaders

QB passing yards: Daniel Jones, 239 yards

Receiving yards: Tyler Warren, 59 yards

Rushing yards: Jonathan Taylor, 96 yards

NFL Week 8: Titans vs. Colts

Get ready for Sunday’s matchup between the Titans and Colts in Week 8 of the National Football League season at Lucas Oil Stadium, which is scheduled to start at 4:25 p.m. ET. We emphasize that all of the NFL predictions and NFL best bets in this preview are derived from 10,000 data-driven simulations of the Titans vs. Colts matchup, and they are correct at the time of publication to help you make better decisions when placing bets at online sportsbooks.

It is important to gamble responsibly and seek trustworthy sources for the latest and most accurate information when making online betting decisions.

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